Microfluidics

Presentation

Our research in microfluidics aims at developing lab-on-a-chips, i.e. performing chemical or biological processing at small-scale. Our activity is organised around the miniaturization of physico-chemical unit operations, such as liquid/liquid separation by membrane pervaporation, continuous flow crystallisation and bubble dissolution in bubbly flow regime. Integrating one or several of these unit operations should lead to innovative and competing lab-on-a-chip devices for the fields of fine chemistry, pharmaceuticals and biotechnology.

Bubbles and droplets are elementary components in microfluidics and deserved a special attention as they are widely used in two-phase microfluidic applications. Therefore, modelling and predicting their dynamics in microchannels is of utmost importance. We therefore investigate on the one hand the dynamics of confined (Taylor) bubbles, and especially the influence of buoyancy and dewetting on the lubrication film. And on the other hand, we study the dynamics of unconfined bubbles in microchannels, paying a special attention to the inertial and capillary migration forces, as well as to the role of surfactants.

Applications to life sciences are also investigated such as cell/cell adhesion in micro channels, micro beads fabrication for protein purification, micro encapsulation of proteins or single-bacterium analysis and sorting.

Researchers

Selected publications

Atasi, O., Haut, B., Pedrono, A., Scheid, B., & Legendre, D. Infuence of soluble surfactants and deformation on the dynamics of centered bubbles in cylindrical microchannels.  Langmuir (published online). 2018

Rivero-Rodriguez, J., & Scheid, B. Bubble dynamics in microchannels: internial and capillary migration forces. Jounal of Fluid Mechanics, 842, 215-247. 2018

Atasi O., Khodaparast S., Scheid B., & Stone H.A. Effect of buoyancy on the motion of a long bubble in a horizontal tube. Physical Review Fluids, 2, 094304. 2017

Ziemecka I., Haut B., & Scheid B. Continuous separation, with microfluidics, of the components of a ternary mixture: from vacuum to purge gas pervaporation. Microfluidics & Nanofluidics, 21, 84. 2017

Petit A.-E., Demotte N., Scheid B., Wildmann C., Bigirimana R., Gordon-Alonso M., Carrasco J., Valitutti S., Godelaine D., & van der Bruggen P. A major secretory defect of tumour-infiltrating T lymphocytes due to galectin impairing LFA-1-mediated synapse completion. Nature Communications, 7, 12242. 2016

Mikaelian D., Haut B., & Scheid B. Bubbly flow and gas-liquid mass transfer in square and circular microchannels for stress-free and rigid interfaces: CFD analysis. Microfluidics & Nanofluidics, 19, 523-545. 2015

Rimez B., Haut B., & Scheid B. Development of a continuous “self-seeding” microfluidic crystallization device for active pharmaceutical ingredients. BIWIC 2014 conference, Rouen (France). 2015

Ziemecka, I., Haut B., & Scheid B. Hydrogen peroxide concentration by pervaporation of a ternary liquid solution in microfluidics. Lab on a chip, 15, 504. 2015

Projects

  • MICROECO project

    Development of scientific bases for the design of bubble microabsorbers. PI : Benoit Scheid

    Funded by INNOVIRIS
  • LEGOMEDIC project

    Development of new strategies for the continuous crystallization of active pharmaceutical ingredients. PI : Benoit Scheid

    Funded by the Walloon Region (MecaTech)
  • OMICRON project

    High flow rate production of porous and functionalized microbeads. PI : Benoit Scheid

    Funded by the Walloon Region (First Spin-Off)
  • PICABO project

    Development of a medical device to improve the safety of blood transfusion. PI : Benoit Scheid

    Funded by the Walloon Region (MecaTech)
  • CARMAPHARM project

    CARbon based MAtrix for PHARMaceutical purpose. PI : Benoit Scheid

    Funded by the Walloon Region (MecaTech)
  • First Entreprise project

    Optimization of the design of a microfluidic chip for the production of adjuvant. PI : Benoit Scheid

    Funded by the Walloon Region (First Entreprise)
  • ARC ESCAPE

    E coli Single Cell Analysis of Persistence. PI : Benoit Scheid

    Funded by ULB